Always an important development opportunity for our young Reds, Travis Binnion's team are set to take on Liverpool in Premier League 2.
The match will kick off at 19:30 BST on Friday 12 April and tickets are still available to purchase.
United's Under-21s last played at Old Trafford in January, when four goals from Sam Mather were enough to seal a 4-2 victory over Norwich City.
And, with the added incentive of Liverpool being our opponents, the young Reds will no doubt be eager to emulate that success this time round.